In the late period of Lyme disease demyelinating involvement of the central nervous system can develop and MS can be erroneously diagnosed; 2007;69 (1):117-9. Epub 2007 Jan 2
Other recognized forms of Lyme include Arthritic Lyme, Cardiac Lyme, Ocular Lyme and Auditory Lyme. Chronic fatigue, chronic pain or fibromyalgia symptoms are common. Coincidentally or not, the term fibromyalgia and chronic fatigue syndrome were coined during the same time period as a resistance to recognizing chronic Lyme disease became the norm.
Some of the other symptoms and conditions that can indicate Lyme disease include constant headaches or migraines, night sweats, heart palpitations, neck pain, jaw and teeth pain, anxiety, sleep disorders, fatigue, memory issues (Lyme fog) and autoimmune disorders.
Less than half of Lyme infected individuals bitten by a tick, develop the classical bulls eye rash or erythema migrans (EM). As a result, many individuals may not realize they are infected. Within weeks of infection, individuals often develop flu-like symptoms and can experience a significant deterioration in their health, either gradually or rapidly. Many do not develop symptoms for years.
When using antibiotics or natural antibacterial remedies, the body can experience a die off of the bacteria. This causes what is known as a Herxheimer reaction or a flare up of the symptoms. The patient can initially feel worse, which may lead them to believe, incorrectly, that they are having an adverse reaction to the remedy. These reactions can actually indicate that the remedy is working. Lyme sufferers may experience many Herxheimer reactions throughout the curative process.
One of the most trusted names in Lyme medicine is that of Robert Bransfield, MD. For those who don’t know who he is, Dr. Bransfield is a practicing psychiatrist from New Jersey who is also a long-time member of the International Lyme and Associated Diseases Society (ILADS). He is a recognized expert in the psychiatric and neurological manifestations of Lyme disease.
Dr. Bransfield published a very important article in December, 2007, in Psychiatric Times (www.psychiatrictimes.com) entitled “Lyme Disease, Comorbid Tick-Borne Diseases, and Neuropsychiatric Disorders”. In this article, written primarily for practicing psychiatrists, he effectively presents the medical aspects of Lyme as it affects the brain with resulting neurological and psychiatric manifestations.
He begins by discussing the fact that Lyme has taken the place of its cousin, syphilis, as the “new great imitator”. But Lyme represents much more a challenge because it is more difficult to diagnose properly and more difficult to eliminate. Combining these two factors with the confusion that is often generated by the presence of co-infections, it makes Lyme medicine the “ultimate” challenge for the average medical practitioner. Frequent symptoms listed by Dr. Bransfield include: fatigue, cognitive impairments, depression, anxiety, irritability, headache, and a multitude of other symptoms. Often fibromyalgia, chronic fatigue syndrome, or multiple sclerosis (MS) has been diagnosed.
Dr. Bransfield suggests that Lyme disease be considered in patients who have no history of previous psychiatric, psychosomatic, or hypochondriacal problems who develop an increasing number of somatic (bodily symptoms), cognitive (mental functioning), neurological, and psychiatric symptoms. Most of the time, he states, a patient will have seen multiple specialists by the time he or she gets to the psychiatrist. Very often he or she will be on tranquilizers and antidepressant medications. Generally, a patient is sent to the psychiatrist for one of three reasons: (1) the symptoms of a patient are unexplainable medically and therefore the referring doctor suspects a psychosomatic or “somatoform” disorder, (2) the mental symptoms are too complex and require psychiatric assessment, or (3) a psychiatrist is needed in order to help manage psychiatric treatments or medications.
Psychiatric manifestations of the tick-borne illnesses are extremely common, and all of the chronic tick-borne infections can cause these manifestations. Anxiety and depression seem to be the main issues that Lyme practitioners most frequently face. Because of the frequency of these problems, the rate of severe psychiatric complications, such as suicide, is very high among tick-borne infection sufferers. Lyme patients (and their families) often describe unusual amounts of “irritability”, often described as having a “short fuse”. Lyme rage, commonly caused by Bartonella or Lyme, can be a significant cause of violence. Severe anxiety in a person with no history of psychiatric problems or in a person where the anxiety is far out of proportion to the life circumstances should be a major clue to the presence of a tick-borne illness. As Dr. Bransfield says, any psychiatric symptom with associated constitutional symptoms (such as arthritis, muscle pain, fatigue, brain fog, etc.) should be thoroughly investigated for Lyme or other tick-borne illness, or be referred to a qualified Lyme practitioner (preferably an ILADS member) for proper evaluation.
2001 : CONCLUSION:
In patients with Erythema migrans, the decreased capability to reduce lipid super oxidants leads to maintaining a high concentration of membrane lipid peroxidation products – Primary whey – GSH-Immunity supplies the Cysteine to the cells so they can replenish their own GSH, the lipid peroxidation product EXTREME EFFICIENCY.
2003 : CONCLUSION:
Cause and effect links between GSH metabolism and diseases such as cancer, neurodegenerative diseases, cystic fibrosis (CF), HIV, LYME and aging have been shown. Polymorphic expression of enzymes involved in GSH homeostasis influences susceptibility and progression of these conditions.
2015 : CONCLUSION:
Agents that affect cell membranes, energy production, and ROS production are generally more active against the B. Burgdorferi persistence than the commonly used antibiotics that inhibit macromolecule biosynthesis.
Klonopin (clonazepam) “depletes the body of essential vitamins, minerals, Melatonin and Glutathione (the body’s master antioxidant).” THIS DRUG CAN BE USED FOR LYME DEPRESSION!
THIS IS EXTREMELY INTERESTING AND INFORMATIVE: ENJOY
LYME INFO NOTE: Dr. Van Konynenburg is a proponent of the Glutathione Depletion–Methylation Cycle Block hypothesis for the pathogenesis of CFS.